Lycopene is responsible for the bright red color in certain foods such as tomatoes. However, lycopene is POSSIBLY … Special Precautions & Warnings: Pregnancy and breast-feeding: Lycopene is LIKELY SAFE during pregnancy and breast-feeding when taken in amounts commonly found in foods. Other sources include apricots, cranberries, grapes, pink grapefruits, guavas, papayas, peaches, and watermelons.2, In North America, nearly 85% of dietary lycopene is derived from tomatoes and tomato-based products.1 Tomatoes have been cultivated since the 16th century as a food source. Lycopene is an antioxidant. As of August 2018, iHerb is using 3rd Party Independent Labs ABC Testing, Eurofins and Alkemist to test product. Top subscription boxes – right to your door, © 1996-2020, Amazon.com, Inc. or its affiliates. Fast & Free shipping on many items! Post-hoc analysis demonstrated a positive dose-response correlation between lycopene concentration and absolute change in EDV response between visits (P = 0.019). Lycopene protected against cancer by activating cancer-preventive phase 2 enzymes.19, 27, Growing evidence exists for the use of lycopene in prostate cancer prevention. Get the best deals on Lycopene Capsule Vitamins & Minerals and stay healthy at home while you shop our large selection & lowest prices at eBay. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Scientific Name(s): Psi-carotene, PsiCommon Name(s): Lycopene. Find patient medical information for Lycopene Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. They combat inflammation, thereby preventing serious ailments like cancer and heart disease. Lycopene also protects your skin, thanks to its photoprotective properties. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. One clinical trial suggested that preventative use of lycopene supplements reduces the spread of localized prostate cancer, but there is no other proof from clinical trials that lycopene can treat cancer. Daily supplements containing up to 120 mg of lycopene have been used safely for up to one year. Change in forearm blood flow from baseline, as measured by endothelium-dependent vasodilatation (EDV), improved significantly in CVD patients (63% higher; P = 0.008) with values that approximated those of healthy volunteers at baseline. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This is because lycopene might slow blood clotting. Updated hourly. Avoid with hypersensitivity to lycopene or to any of its food sources, especially tomatoes. Lycopene administered as a pure compound has been studied in clinical trials at dosages of 8 to 75 mg/day.66, 80, 81, 82, 83, 84 Lycopene is primarily available in capsule and softgel form, with dosage guidelines from manufacturers ranging from 10 to 30 mg taken twice daily with meals. Using a 3rd Party Independent Lab guarantees that the results are objective and unbiased. Also related to its powerful antioxidative qualities, lycopene plays a role in … Lycopene is a common carotenoid compound found in fruits, vegetables, and green plants.1 It is responsible for a red plant pigment found primarily in tomatoes. Natural sources primarily contain the all-trans form of lycopene; the cis form of lycopene is more bioavailable and is less likely to precipitate and form crystals.11, 12. Manufacturer of Capsules - Prebiotic & Probiotic, 100 % Lycopene With Multi Vitamin, Calcium Carbonate 200mg Alphacalcidol 0.25mcg and Silymarin B-Complex … Lycopene is primarily available in capsule and softgel form, with dosage guidelines from manufacturers ranging from 10 to 30 mg taken twice daily with meals. turmeric, saw palmetto, Ginkgo Biloba, garlic, echinacea. Lycopene administered as a pure compound has been studied in clinical trials at dosages of 7 to 75 mg/day. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. There are several published studies that evaluate whether lycopene in tomato products or supplements could have protective effects against prostate cancer and cardiovascular disease. Over 600 carotenoids have been identified in nature! Check price at AmazonNOW Lycopene keeps it basic, but this formulation has a solid dosage of 20 mg of lycopene per capsule, which is delivered in rice bran oil and a gelatin capsule. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Lycopene intake and decreased cancer risk association has been observed in stomach cancers.37 Lycopene's protective role in the early stages of cervical carcinogenesis was noted in 1 study.38 Plasma levels of lycopene and other carotenoids were lower in women with cervical intraepithelial neoplasia and cervical cancer, suggesting a protective effect of higher lycopene concentrations.39, 40, Lycopene was more efficient than any carotenoid in inhibiting insulin-like growth factor type 1 (ie, high levels of this growth factor are related to an increased risk of cancer) in patients with a higher risk of colorectal cancer.31, 32 A meta-analysis of observational studies explored lycopene consumption and associated risk of colorectal cancer. One trial documented a cancer-related hemorrhage in a patient taking lycopene, but causality was unclear.98 Tomato-based products are acidic and may irritate stomach ulcers. Lycopene is part of the caratonoid group of substances. Clinical studies evaluating the benefits of supplemental lycopene in pre-eclampsia have produced conflicting results, and some evidence of harm has been reported.95, 96 The amount of lycopene in foods is assumed to be safe. The mechanism of action may be associated with antioxidant activity, as well as decreased cell surface adhesion molecule expression and intima-media thickness. The lycopene in supplements is about as easy for the body to use as lycopene found in food. However, after exclusion of breast cancer cases diagnosed during the first 2 years of follow-up, the association was no longer statistically significant.25 A pooled analysis of 8 prospective studies on carotenoids and breast cancer demonstrated a statistically significant inverse association between carotenoid levels, including lycopene concentrations, and the risk of breast cancer.26, In a large case-control study (N = 4,721) covering 3 years, the risk of pancreatic cancer for men consuming lycopene was reduced 31%. Christopher Columbus may have learned of the nutritional benefits of fruits and tomatoes from the inhabitants of the New World.3 There is a large body of evidence documenting the health benefits of lycopene, as well as its biological activity in numerous human diseases.1, 2, 3, Lycopene is a 40-carbon acyclic carotenoid containing 11 conjugated double bonds, with a molecular mass of 536.2, 4, 5 It consists of only hydrogen and carbon atoms, and is 1 of 600 carotenoids synthesized by plants and photosynthetic microorganisms.2, 4 The biochemistry of lycopene is unique because it has no pro-vitamin A activity, unlike many other carotenoids, such as alpha-carotene and beta-carotene. The amount of lycopene in food is assumed to be safe. One report found beta-carotene to be active in wound healing, while lycopene was inactive.62 Other studies document that lycopene or tomato-derived products rich in lycopene provide photoprotective effects against ultraviolet light-induced erythema.63, 64, 65 Higher levels of lycopene antioxidants in the skin effectively led to lower levels of skin roughness.15 In a placebo-controlled study, lycopene effectively managed oral lichen planus.66, In some animal models, lycopene reduced diabetes-induced learning and memory impairment by decreasing oxidative stress and inflammation.67 Lycopene may also attenuate diabetic neuropathic pain by inhibiting action of tumor necrosis factor (TNF)-alpha and nitric oxide.68 Lycopene may be useful in patients with type 2 diabetes by suppressing oxidative stress and enhancing innate immunity or serum levels of immunoglobulin M.69, Reports are available in the International Symposia on Lycopene and Tomato Products in Disease Prevention.70, 71 Reviews describing lycopene and disease prevention are also available.72, 73, 74, 75, Epidemiological studies have found that lycopene decreased the inflammation marker C reactive protein.13 The production of inflammatory mediators, such as TNF-alpha, was reduced in patients consuming a tomato-based drink.76 Asthmatic adults receiving lycopene treatment experienced improvement in airway inflammation. Scientific literature documents lycopene’s antioxidant activity and its use in cancer prevention (breast and prostate), as well as its use in the prevention of cardiovascular disease. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. What Is Lycopene? Lycopene was 2- to 10-fold more efficient in quenching singlet oxygen than were alpha-tocopherol and beta-carotene.13 The antioxidant activity of lycopene may also be mediated by its bioactive metabolites.14, One study involving 20 patients found a correlation between skin roughness and lycopene dietary concentration.15 In an 8-week, double-blind, randomized, placebo-controlled trial, lycopene supplementation decreased DNA oxidative damage.16 Lycopene may also ameliorate the oxidative stress of cigarette smoke.17, 18, A sponsor-funded phase II placebo-controlled randomized clinical trial (n = 57) conducted in men with benign prostatic hypertrophy (BPH) found a commercially available herbal formulation containing pumpkin seed oil, lycopene, saw palmetto, pygeum, and Epilobium parviflorum to significantly reduce median prostate specific scores as well as day time and night time urinary frequency. Information regarding safety and efficacy in pregnancy and lactation is lacking. Lycopene is a powerful antioxidant, which means that, among nutrients, it has a greater-than-average ability to “quench” free radicals that cause damage to cells. For each 5 mg/day increase in lycopene intake, prostate cancer risk decreased with no heterogeneity in studies.115 Oxidative stress is recognized as a major contributor to increased cancer risk. SKU: LY3, Swanson Super-Strength LYC-O-Mato Lycopene 40 Milligrams 60 Sgels, Oregon's Wild Harvest Prostate Health with Lycopene Capsules, 60 Count, Healthy Origins LYC-O-Mato Lycopene 15 Mg, 60 Softgels, Spring Valley Lycopene 10 mg, Prostate Health, 60 Softgels (Pack of 2), 21st Century Lycopene 25 mg Tablets, 60 Count (22400), Solaray Lycopene, Softgel (Btl-Plastic) 10mg | 60ct, 21st Century Lycopene 25 Mg Tablets, 60-Count (Pack of 3), Lycopene 30 mg All Natural Prostate Supplements for Men. There are numerous studies on the uses of lycopene in treating cancer and cardiovascular disease, as well as on its antioxidant and anti-inflammatory activity. Based on the results of 5 relevant studies with no substantial heterogeneity, lycopene showed no significant association with cataract risk.101, Lycopene may be effective as a first-line therapy in treating oral submucous fibrosis56 and in combination with other therapies in treating gingivitis.57 A randomized, double-blind, placebo-controlled trial (n = 50) found no difference between groups treated with lycopene-enriched olive oil or placebo (water) for treatment of burning mouth syndrome or its symptoms.104, Reports of positive outcomes with beta-carotene in skin disorders including cancer, pigment imbalance, and photodermatoses, are available,58, 59, 60, 61 but lycopene may not share these effects because of its structural configuration. Scientific literature documents some GI complaints, such as diarrhea, dyspepsia, gas, nausea, and vomiting. For years, scientists noted that diets high in beta-carotene FROM FOOD SOURCES, reduced risk of many types of cancer, including lung cancer in smokers. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. “Cipla is a 83-year old start-up. Although numerous animal studies exist,4 only clinical evidence was reviewed in the following studies. Bottom Line Lycopene is a plant nutrient with antioxidant properties. Lycopene absorption in humans is approximately 10% to 30%, with the remaining excreted.1 The half-life elimination of lycopene in plasma was estimated to be 12 to 33 days, while a single-dose pharmacokinetic study documented 28 to 61 hours.85 The estimated daily dietary intake of the general population is 0.5 to 27 mg per person per day.86 Factors affecting uptake and absorption of carotenoids have been reported.87 Pharmacokinetic parameters of lycopene have been evaluated in humans.39, 88, 89, 90, 91, 92, 93, 94, Information regarding safety and efficacy in pregnancy and lactation is lacking. May being the operative word. Lycopene is LIKELY SAFE when taken by mouth in appropriate amounts. Elimination of 1 study with wide confidence intervals revealed a significant inverse association between dietary intake as well as blood concentrations of lycopene and prostate cancer risk.108 A meta-analysis of 21 studies provided further evidence of diets rich in tomatoes providing protection against prostate cancer.19 In a Cochrane review of randomized controlled trials of lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer, only 3 of 64 published studies with 154 participants met inclusion criteria. Last updated on Jan 20, 2020. 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No significant changes were seen in arterial stiffness or blood pressure between lycopene- and placebo-treated groups. + Vitamin B1 2 mg + Vitamin D3 200 IU + Vitamin B6 1.5 mg + Vitamin B12 1 mcg + Vitamin E 10 IU + Vitamin C 50 mg + Niacinamide 20 mg + Calcium pantothenate 5 mg + Folic Acid 0.3 mg + Ferrous Fumarate 90 mg + Copper 0.5 mg + B Carotene 10% 4.77 + Ginseng 45 mg + Lutein 8% 3 mg + Potassium Sulphate 2 mg Puritans Pride Lycopene 20 Mg Softgels, 60 Count, Puritan's Pride Lycopene 40 mg, Supplement for Prostate and Heart Health Support**, Contains Antioxidant Properties**, 60 Rapid Release Softgels, Jarrow Formulas CarotenAll for Cardiovascular and Vision Health, 60 Soft gels, Puritans Pride Lycopene 10 Mg Softgels, 100 Count, NOW Supplements, Lycopene 20 mg with Natural Extract from Tomatoes, Free Radical Scavenger*, 50 Softgels, Lycopene & Lutein Complex 50MG 200 Veggie Capsules (Non-GMO & Gluten Free) Antioxidant Natural Tomato Great for Prostate Health, Immune System Support, Heart Health, Eyesight Support, NOW Supplements, Lycopene 10 mg with Natural Extract from Tomatoes, Free Radical Scavenger*, 60 Softgels, Lycopene 20mg Per Serving - 200 Capsules - Lycopene Supplement - Super Antioxidant which Helps Support Immune System and Prostate Health, Swanson Lycopene Supplement, Prostate Health Supplement 20 mg, 60 Softgels, Healthy Origins LYC-O-Mato Lycopene (Non-GMO) 15 mg, 180 Softgels, Lycopene 50mg 180 Vegetarian Capsules | Supplement for Prostate & Heart Health | Antioxidant Natural Tomato Extract Non-GMO | Supports Immune System & Helps Reduce Free Radical Damage - Pure Powder, Spring Valley - Lycopene 10 mg, 60 Softgels, Life Extension Mega Lycopene Extract 15 Mg, 90 softgels (00455), 2 Bottles Lycopene 50mg 180 Total Capsules KRK Supplements, Lycopene 50mg x 180 Tablets (6 Months Supply). Gardian Capsules, Cipla The drug brand named Gardian Capsules contains generic salt-Choline and is manufactured by Cipla. Lycogard Capsule may also be used for purposes not listed in this medication guide. Lycopene Claims The Science (or Lack Thereof) Behind Lycopene Word on the Street About Lycopene The Bottom Line: Are Lycopene Supplements Worth a Try? As a dietary supplement, a person may take this helpful carotinoid in the form of a lycopene capsule, tincture, or powder. Participants received lycopene 7 mg or placebo daily for 2 months. No association was found between lycopene levels and prostate cancer risk.35 However, a dose-response meta-analysis of 26 studies, 17,517 cases of prostate cancer and 563,299 participants, published through April 2014 identified a linear inverse relationship between lycopene intake and risk of prostate cancer with a dose threshold between 9 and 21 mg/day and an effective plasma concentration found not to exceed 85 mcg/L. Lycopene 6% 2500 mcg + Vitamin A 2500 I.U. Meta-analysis revealed no difference in prostate-specific antigen levels or in lycopene levels with and without lycopene supplementation. Lycopene extract is usually low in cost and readily available in most health food stores. 2 Months, danshen, garlic, echinacea in cost and readily available most. Lycopene found in food is assumed to be safe protective effects against prostate cancer and disease! Molecule expression and intima-media thickness material is provided for educational purposes only or its.... Are interested in pigment that gives some vegetables and fruits their red color the caratonoid of. Have been used safely for up to one year has been studied clinical! Responsible for the bright red color in certain foods such as tomatoes, look here to find an easy to. 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